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CHLORPYRIFOS
ICSC: 0851
Peer-Review Status: 19.10.2005 Validated
O,O-Diethyl-O-(3,5,6-trichloro-2-pyridyl)phosphorothioate
O,O-Diethyl O-(3,5,6-trichloro-2-pyridinyl) phosphorothioic acid ester
Chlorpyrifos-ethyl 
CAS #: 2921-88-2 RTECS #: TF6300000
UN #: 2783
EC #: 015-084-00-4
EINECS #: 220-864-4
 		    Formula: C9H11Cl3NO3PS
Molecular mass: 350.6

TYPES OF
HAZARD /
EXPOSURE 		ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames.  Use water spray, foam, powder, carbon dioxide. 
EXPLOSION      
 
EXPOSURE   STRICT HYGIENE! AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN!  IN ALL CASES CONSULT A DOCTOR! 
Inhalation Pupillary constriction, muscle cramp, excessive salivation. Sweating. Dizziness. Nausea. Vomiting. Diarrhoea. Muscle twitching. Convulsions. Unconciousness.  Use local exhaust or breathing protection.  Fresh air, rest. Artificial respiration may be needed. Refer for medical attention. 
Skin MAY BE ABSORBED! See Inhalation.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention . 
Eyes Blurred vision.  Wear face shield or eye protection in combination with breathing protection if powder.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion See Inhalation.  Do not eat, drink, or smoke during work. Wash hands before eating.  Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Give a slurry of activated charcoal in water to drink. Refer immediately for medical attention. 

SPILLAGE DISPOSAL
 		PACKAGING & LABELLING
Personal protection: chemical protection suit including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.  Do not transport with food and feedstuffs.
Severe marine pollutant. 
EC Classification
Symbol: T, N; R: 25-50/53; S: (1/2)-45-60-61 
UN Classification
UN Hazard Class: 6.1; UN Pack Group: III 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-61GT7-III.  Store in an area without drain or sewer access. Keep in a well-ventilated room. Separated from strong bases, strong acids and food and feedstuffs. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS-TO-WHITE CRYSTALS WITH CHARACTERISTIC ODOUR. 

Physical dangers
No data. 

Chemical dangers
Decomposes at approximately 160°C. This produces toxic and corrosive fumes including hydrogen chloride, phosgene, phosphorus oxides, nitrogen oxides and sulfur oxides. Reacts with strong bases and acids. 

Occupational exposure limits
TLV: 0.1mg/m³ as TWA; (skin); A4 (not classifiable as a human carcinogen); BEI issued; (ACGIH 2005). 

Routes of exposure
The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion. 

Inhalation risk
A harmful concentration of airborne particles can be reached quickly on spraying or when dispersed, especially if powdered. 

Effects of short-term exposure
The substance may cause effects on the nervous system. This may result in convulsions and respiratory depression. Cholinesterase inhibition. Exposure far above the OEL could cause death. The effects may be delayed. Medical observation is indicated. 

Effects of long-term or repeated exposure
Cholinesterase inhibition. Cumulative effects are possible. See Acute Hazards/Symptoms. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Decomposes at 160°C
Melting point: 41-42°C
Density: 1.4 g/cm³
Solubility in water, mg/l at 25°C: 1.4 (very poor)
Vapour pressure, Pa at 25°C: 0.0024
Octanol/water partition coefficient as log Pow: 4.7/5.27   		The substance is very toxic to aquatic organisms. This substance may be hazardous to the environment. Special attention should be given to birds and bees. Bioaccumulation of this chemical may occur along the food chain, for example in fish and algae. The substance may cause long-term effects in the aquatic environment. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal. 

NOTES
If the pesticide is present in a formulation containing hydrocarbon solvents, vomiting should not be induced.
Depending on the degree of exposure, periodic medical examination is suggested.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
If the substance is formulated with solvents also consult the ICSCs of these materials.
Carrier solvents used in commercial formulations may change physical and toxicological properties.
Do NOT take working clothes home. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety 		WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information. 
    See Also:
       Toxicological Abbreviations
       Chlorpyrifos (PDS)
       Chlorpyrifos (WHO Pesticide Residues Series 2)
       Chlorpyrifos (WHO Pesticide Residues Series 5)
       Chlorpyrifos (Pesticide residues in food: 1977 evaluations)
       Chlorpyrifos (Pesticide residues in food: 1981 evaluations)
       Chlorpyrifos (Pesticide residues in food: 1982 evaluations)
       Chlorpyrifos (Pesticide residues in food: 1983 evaluations)
       Chlorpyrifos (JMPR Evaluations 1999 Part II Toxicological)