IPCS INCHEM Home
EPN
ICSC: 0753
Peer-Review Status: 11.11.2008 Validated
Phosphonothioic acid, phenyl-, O-ethyl O-(4-nitrophenyl) ester
O-Ethyl O-4-nitrophenyl phenyl phosphonothioate 
CAS #: 2104-64-5 RTECS #: TB1925000
UN #: 2783
EC #: 015-036-00-2
EINECS #: 218-276-8
    Formula: C14H14NO4PS
Molecular mass: 323.3

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames.  Use powder, alcohol-resistant foam, water spray, carbon dioxide. 
EXPLOSION      
 
EXPOSURE   PREVENT DISPERSION OF DUST! STRICT HYGIENE! AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN!  IN ALL CASES CONSULT A DOCTOR! 
Inhalation Dizziness. Pupillary constriction. Muscle cramps. Excessive salivation. Sweating. Muscle twitching. Nausea.  Use local exhaust or breathing protection.  Fresh air, rest. Half-upright position. Artificial respiration may be needed. Refer immediately for medical attention. 
Skin MAY BE ABSORBED! Redness. Pain. Further see Inhalation.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer immediately for medical attention. Wear protective gloves when administering first aid. Put clothes in sealable container. See Notes. 
Eyes Redness. Blurred vision.  Wear face shield or eye protection in combination with breathing protection if powder. Wear safety spectacles.  Rinse with plenty of water for several minutes (remove contact lenses if easily possible). Refer immediately for medical attention. 
Ingestion Nausea. Abdominal cramps. Vomiting. Diarrhoea. Drowsiness. Further see Inhalation.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer immediately for medical attention. 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT wash away into sewer. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting.  Do not transport with food and feedstuffs.
Severe marine pollutant. 
EC Classification
Symbol: T+, N; R: 27/28-50/53; S: (1/2)-22-36/37-45-60-61 
UN Classification
UN Hazard Class: 6.1; UN Pack Group: I 
GHS Classification
Signal: Danger
Fatal if swallowed
Fatal if inhaled
Fatal in contact with skin
Causes damage to nervous system
Very toxic to aquatic life with long lasting effects 
skull;toxiccancer;health hazenviro;aqua

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-61GT7.  Separated from strong oxidizers and food and feedstuffs. Well closed. Provision to contain effluent from fire extinguishing. Store in an area without drain or sewer access. 

IMPORTANT DATA
Physical State; Appearance
YELLOW CRYSTALLINE POWDER WITH CHARACTERISTIC ODOUR. 

Physical dangers
 

Chemical dangers
Decomposes on heating. This produces toxic and corrosive fumes including nitrogen oxides, phosphorus oxides and sulfur oxides. Reacts with strong oxidants. This generates fire and explosion hazard. Decomposes under the influence of bases. This produces p-nitrophenol (see ICSC 0066). 

Occupational exposure limits
TLV (inhalable fraction): 0.1mg/m³ as TWA; (skin); A4 (not classifiable as a human carcinogen); BEI issued; (ACGIH 2008).
MAK (inhalable fraction): 0.5 mg/m³; Peak limitation category: II(2); Skin absorption (H); (DFG 2008). 

Routes of exposure
The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion. 

Inhalation risk
A harmful concentration of airborne particles can be reached quickly. 

Effects of short-term exposure
The substance is irritating to the eyes and skin. Cholinesterase inhibition. The substance may cause effects on the nervous system. This may result in convulsions and respiratory failure. Exposure could cause unconsciousness and death. The effects may be delayed. Medical observation is indicated. 

Effects of long-term or repeated exposure
Cholinesterase inhibition. Cumulative effects are possible. See Acute Hazards/Symptoms. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point at 0.667kPa: 215°C
Melting point: 36°C
Density: 1.3 g/cm³
Solubility in water: none
Vapour pressure, Pa at 25°C: <0.01
Octanol/water partition coefficient as log Pow: 4.78  
The substance is very toxic to aquatic organisms. Bioaccumulation of this chemical may occur in fish. The substance may cause long-term effects in the aquatic environment. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal. 

NOTES
Depending on the degree of exposure, periodic medical examination is suggested.
Isolate contaminated clothing by sealing in a bag or other container.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
Carrier solvents used in commercial formulations may change physical and toxicological properties.
Do NOT take working clothes home. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations