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ACEPHATE
ICSC: 0748
Peer-Review Status: 18.10.2001 Validated
O,S-Dimethyl acetylphosphoramidothioate
Phosphoramidothioic acid, acetyl-, O,S-dimethyl ester
N-(Methoxy(methylthio)phosphinoyl)acetamide 
CAS #: 30560-19-1 RTECS #: TB4760000
EC #: 015-079-00-7
EINECS #: 250-241-2
    Formula: C4H10NO3PS
Molecular mass: 183.2

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire.    In case of fire in the surroundings, use appropriate extinguishing media. 
EXPLOSION      
 
EXPOSURE   PREVENT DISPERSION OF DUST! AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN!   
Inhalation Pupillary constriction, muscle cramp, excessive salivation. Sweating. Nausea. Dizziness. Laboured breathing. Convulsions.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Half-upright position. Refer for medical attention. 
Skin   Protective gloves.  Rinse skin with plenty of water or shower. 
Eyes   Wear safety spectacles.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Abdominal cramps. Vomiting. Diarrhoea. See Inhalation.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Rest. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.   
EC Classification
Symbol: Xn; R: 22; S: (2)-36 
UN Classification
 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
  Separated from food and feedstuffs. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS CRYSTALS OR WHITE POWDER WITH CHARACTERISTIC ODOUR. 

Physical dangers
 

Chemical dangers
Decomposes on heating. This produces toxic fumes including nitrogen oxides, phosphorus oxides and sulfur oxides. 

Occupational exposure limits
TLV (NOT-ESTABLISHED):. 

Routes of exposure
The substance can be absorbed into the body by ingestion and by inhalation of its aerosol. 

Inhalation risk
A harmful concentration of airborne particles can be reached quickly on spraying or when dispersed, especially if powdered. 

Effects of short-term exposure
The substance may cause effects on the nervous system and blood. This may result in cholinesterase inhibition. Medical observation is indicated. The effects may be delayed. 

Effects of long-term or repeated exposure
 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Melting point: 92-93°C
Density: 1.4 g/cm³
Solubility in water, g/100ml at 20°C: 79
Vapour pressure, Pa at 24°C: 0.0002
Octanol/water partition coefficient as log Pow: -0.9  
This substance may be hazardous to the environment. Special attention should be given to crustacea, birds and bees. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal. 

NOTES
Depending on the degree of exposure, periodic medical examination is suggested.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
If the substance is formulated with solvents also consult the ICSCs of these materials.
Carrier solvents used in commercial formulations may change physical and toxicological properties. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations
       Acephate (Pesticide residues in food: 1976 evaluations)
       Acephate (Pesticide residues in food: 1979 evaluations)
       Acephate (Pesticide residues in food: 1981 evaluations)
       Acephate (Pesticide residues in food: 1982 evaluations)
       Acephate (Pesticide residues in food: 1984 evaluations)
       Acephate (Pesticide residues in food: 1984 evaluations)
       Acephate (Pesticide residues in food: 1987 evaluations Part II Toxicology)
       Acephate (Pesticide residues in food: 1988 evaluations Part II Toxicology)
       Acephate (Pesticide residues in food: 1990 evaluations Toxicology)
       Acephate (JMPR Evaluations 2002 Part II Toxicological)
       Acephate (JMPR Evaluations 2005 Part II Toxicological)