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TRIMETHYL PHOSPHATE
ICSC: 0686
Peer-Review Status: 26.10.2004 Validated
Phosphoric acid trimethyl ester
Trimethyl orthophosphate 
CAS #: 512-56-1 RTECS #: TC8225000
EINECS #: 208-144-8
    Formula: C3H9O4P / (CH3O)3PO
Molecular mass: 140.1

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames.  Use water spray, alcohol-resistant foam, dry powder, carbon dioxide. 
EXPLOSION      
 
EXPOSURE   AVOID ALL CONTACT!   
Inhalation Cough. Sore throat.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Refer for medical attention. 
Skin Redness.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse skin with plenty of water or shower. 
Eyes Redness.  Wear safety goggles.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Shortness of breath. Weakness. Hyperexcitability. Tremor.  Do not eat, drink, or smoke during work.  Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: chemical protection suit including self-contained breathing apparatus. Ventilation. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations.   
EC Classification
 
UN Classification
 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
  Separated from strong oxidants and strong bases. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS LIQUID. 

Physical dangers
 

Chemical dangers
Decomposes on burning. This produces toxic fumes including phosphorus oxides. Reacts with strong bases and strong oxidants. May explode on heating during large scale atmospheric pressure distillation. 

Occupational exposure limits
TLV (NOT-ESTABLISHED):.
MAK: Carcinogen category: 3B; Germ cell mutagen group: 2; Skin absorption (H); (DFG 2004). 

Routes of exposure
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. 

Inhalation risk
No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20°C. 

Effects of short-term exposure
The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the nervous system. 

Effects of long-term or repeated exposure
The substance may have effects on the nervous system. This may result in flaccid paralysis. May cause heritable genetic damage to human germ cells. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 197.2°C
Melting point: -46°C
Relative density (water = 1): 1.2
Solubility in water, g/100ml at 25°C: 50 (good)
Vapour pressure, kPa at 20°C: 0.11
Flash point: 107°C
Octanol/water partition coefficient as log Pow: -0.52,-0.78  
 

NOTES
 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations
       Trimethyl phosphate (SIDS)