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THEOPHYLLINEICSC: 0678
3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione
1,3-Dimethylxanthine
April 2007
CAS #: 58-55-9
UN #: 1544
EC Number: 200-385-7

  ACUTE HAZARDS PREVENTION FIRE FIGHTING
FIRE & EXPLOSION Not combustible. Gives off irritating or toxic fumes (or gases) in a fire.        In case of fire in the surroundings, use appropriate extinguishing media.   

   
  SYMPTOMS PREVENTION FIRST AID
Inhalation See Ingestion.  Avoid inhalation of dust and mist.  Fresh air, rest. 
Skin   Protective gloves.  Remove contaminated clothes. Rinse skin with plenty of water or shower. 
Eyes   Wear safety spectacles.  Rinse with plenty of water for several minutes (remove contact lenses if easily possible). 
Ingestion Headache. Nausea. Vomiting. Irritability. Palpitations. Convulsions.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention . 

SPILLAGE DISPOSAL CLASSIFICATION & LABELLING
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Then store and dispose of according to local regulations. 

According to UN GHS Criteria

skull;toxiccancer;health haz
DANGER
Toxic if swallowed
May be harmful if inhaled
May cause harm to breast-fed children
Causes damage to vascular system and kidneys
Causes damage to the kidneys through prolonged or repeated exposure 

Transportation
UN Classification
UN Hazard Class: 6.1; UN Pack Group: III 

STORAGE
Separated from food and feedstuffs. 
PACKAGING
Do not transport with food and feedstuffs. 
THEOPHYLLINE ICSC: 0678
PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
WHITE CRYSTALLINE POWDER. 

Physical dangers
 

Chemical dangers
Decomposes on heating. This produces toxic fumes including nitrogen oxides. 

Formula: C7H8N4O2
Molecular mass: 180.2
Melting point: 270-274°C
Density: g/cm³
Solubility in water: moderate
Vapour pressure: negligible
Octanol/water partition coefficient as log Pow: -0.02 (estimated) 


EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body in hazardous amounts by ingestion. 

Effects of short-term exposure
The substance may cause effects on the heart and central nervous system. This may result in cardiac dysrhythmia and convulsions. The effects may be delayed. 

Inhalation risk
A nuisance-causing concentration of airborne particles can be reached quickly when dispersed. 

Effects of long-term or repeated exposure
 


OCCUPATIONAL EXPOSURE LIMITS
 

ENVIRONMENT
 

NOTES
 

ADDITIONAL INFORMATION
  EC Classification
 

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    See Also:
       Toxicological Abbreviations
       Theophylline (IARC Summary & Evaluation, Volume 51, 1991)