IPCS INCHEM Home
THEOPHYLLINE
ICSC: 0678
Peer-Review Status: 18.04.2007 Validated
3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione
1,3-Dimethylxanthine 
CAS #: 58-55-9 RTECS #: XH3850000
UN #: 1544
EINECS #: 200-385-7
    Formula: C7H8N4O2
Molecular mass: 180.2

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Not combustible. Gives off irritating or toxic fumes (or gases) in a fire.    In case of fire in the surroundings, use appropriate extinguishing media. 
EXPLOSION      
 
EXPOSURE      
Inhalation See Ingestion.  Avoid inhalation of dust and mist.  Fresh air, rest. 
Skin   Protective gloves.  Remove contaminated clothes. Rinse skin with plenty of water or shower. 
Eyes   Wear safety spectacles.  Rinse with plenty of water for several minutes (remove contact lenses if easily possible). 
Ingestion Headache. Nausea. Vomiting. Irritability. Palpitations. Convulsions.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Then store and dispose of according to local regulations.  Do not transport with food and feedstuffs. 
EC Classification
 
UN Classification
UN Hazard Class: 6.1; UN Pack Group: III 
GHS Classification
Signal: Danger
Toxic if swallowed
May be harmful if inhaled dust
May cause harm to breast-fed children
Causes damage to vascular system and kidneys
Causes damage to kidneys through prolonged or repeated exposure 
skull;toxiccancer;health haz

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-61GT2-III.  Separated from food and feedstuffs. 

IMPORTANT DATA
Physical State; Appearance
WHITE CRYSTALLINE POWDER. 

Physical dangers
 

Chemical dangers
Decomposes on heating. This produces toxic fumes including nitrogen oxides. 

Occupational exposure limits
TLV (NOT-ESTABLISHED):. 

Routes of exposure
The substance can be absorbed into the body in hazardous amounts by ingestion. 

Inhalation risk
A nuisance-causing concentration of airborne particles can be reached quickly when dispersed. 

Effects of short-term exposure
The substance may cause effects on the heart and central nervous system. This may result in cardiac dysrhythmia and convulsions. The effects may be delayed. 

Effects of long-term or repeated exposure
 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Melting point: 270-274°C
Density: g/cm³
Solubility in water: moderate
Vapour pressure: negligible
Octanol/water partition coefficient as log Pow: -0.02 (estimated) 
 

NOTES
 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations
       Theophylline (IARC Summary & Evaluation, Volume 51, 1991)