N-METHYL-2-PYRROLIDONE (ICSC)

N-METHYL-2-PYRROLIDONE	ICSC: 0513

Date of Peer Review: April 1997

1-Methyl-2-pyrrolidinone
1-Methyl-2-pyrrolidone
N-Methylpyrrolidone

CAS #	872-50-4	C₅H₉NO
RTECS #	UY5790000	Molecular mass: 99.1
UN #
EC Index #	606-021-00-7

TYPES OF HAZARD / EXPOSURE	ACUTE HAZARDS / SYMPTOMS	PREVENTION	FIRST AID / FIRE FIGHTING
FIRE	Combustible. Gives off irritating or toxic fumes (or gases) in a fire.	NO open flames.	Powder, alcohol-resistant foam, water spray, carbon dioxide.
EXPLOSION	Above 96°C explosive vapour/air mixtures may be formed.	Above 96°C use a closed system, ventilation.

EXPOSURE		PREVENT GENERATION OF MISTS!
Inhalation	Headache.	Ventilation.	Fresh air, rest. Refer for medical attention.
Skin	MAY BE ABSORBED! Dry skin. Redness.	Protective gloves. Protective clothing.	Remove contaminated clothes. Rinse skin with plenty of water or shower.
Eyes	Redness. Pain. Blurred vision.	Safety spectacles.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
Ingestion		Do not eat, drink, or smoke during work.	Rinse mouth. Do NOT induce vomiting. Refer for medical attention.

SPILLAGE DISPOSAL

PACKAGING & LABELLING

Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place. Personal protection: filter respirator for organic gases and vapours.

EU Classification
Symbol: Xi
R: 36/38
S: (2-)-41
UN Classification

EMERGENCY RESPONSE

STORAGE

NFPA Code: H2; F1; R0

Separated from oxidants, rubber, plastics, aluminium, light metals. Dry. Ventilation along the floor.

IPCS
International
Programme on
Chemical Safety

Prepared in the context of cooperation between the International Programme on Chemical Safety and the Commission of the European Communities Š IPCS, CEC 2005

SEE IMPORTANT INFORMATION ON BACK

N-METHYL-2-PYRROLIDONE

ICSC: 0513

IMPORTANT DATA

PHYSICAL STATE; APPEARANCE:
COLOURLESS HYGROSCOPIC LIQUID, WITH CHARACTERISTIC ODOUR. TURNS YELLOW ON EXPOSURE TO HEAT.

CHEMICAL DANGERS:
The substance decomposes on heating or on burning producing toxic fumes including nitrogen oxides, carbon monoxide. Attacks aluminium, light metals, rubber, plastic.

OCCUPATIONAL EXPOSURE LIMITS:
TLV not established.
MAK: 20 ppm, 82 mg/mł; Peak limitation category: II(2); skin absorption (H); Pregnancy risk group: C; (DFG 2005).

ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation and through the skin.

INHALATION RISK:
A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance irritates the eyes and the skin. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:
Repeated or prolonged contact with skin may cause dermatitis. Animal tests show that this substance possibly causes toxic effects upon human reproduction.

PHYSICAL PROPERTIES

Boiling point: 202°C
Melting point: -24°C
Relative density (water = 1): 1.03
Solubility in water: very good
Vapour pressure, Pa at 25°C: 66
Relative vapour density (air = 1): 3.4

Relative density of the vapour/air-mixture at 20°C (air = 1): 1.00
Flash point: 96°C o.c.
Auto-ignition temperature: 270°C
Explosive limits, vol% in air: 0.99-3.9

ENVIRONMENTAL DATA

NOTES

N-Methyl-2-pyrrolidone enhances the skin permeability for other substances. Insufficient data are available on the effect of this substance on human health, therefore utmost care must be taken. Card has been partly updated in October 2005. See section Occupational Exposure Limits.

ADDITIONAL INFORMATION

LEGAL NOTICE

Neither the CEC nor the IPCS nor any person acting on behalf of the CEC or the IPCS is responsible for the use which might be made of this information

Š IPCS, CEC 2005

    See Also:
       Toxicological Abbreviations
       Methyl-2-pyrrolidone, n- (CICADS 35, 2001)