IPCS INCHEM Home
1,4-BENZENEDIAMINE DIHYDROCHLORIDE
ICSC: 0386
Peer-Review Status: 19.10.1999 Validated
1,4-Phenylenediamine dihydrochloride
1,4-Diaminobenzene dihydrochloride
4-Aminoaniline dihydrochloride
p-Phenylenediamine dihydrochloride 
CAS #: 624-18-0 RTECS #: ST0350000
UN #: 1673
EC #: 612-029-00-1
EINECS #: 210-834-9
    Formula: C6H8N2. 2HCl / C6H4(NH2)2 . 2HCl
Molecular mass: 181.1

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames.  Use water spray, foam, powder, carbon dioxide. 
EXPLOSION Finely dispersed particles form explosive mixtures in air.  Closed system, ventilation, explosion-proof electrical equipment and lighting. Prevent deposition of dust.   
 
EXPOSURE   PREVENT DISPERSION OF DUST! STRICT HYGIENE!   
Inhalation Dizziness. Headache. Laboured breathing. Blue lips, fingernails and skin. Confusion. Convulsions. Nausea. Unconciousness.  Use local exhaust or breathing protection.  Fresh air, rest. Refer for medical attention. 
Skin   Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention . 
Eyes Redness.  Wear safety goggles or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion See Inhalation.  Do not eat, drink, or smoke during work.  Rinse mouth. Refer for medical attention . Induce vomiting (ONLY IN CONSCIOUS PERSONS!). 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: chemical protection suit including self-contained breathing apparatus. Sweep spilled substance into covered containers. Carefully collect remainder. Then store and dispose of according to local regulations.  Do not transport with food and feedstuffs. 
EC Classification
Symbol: T, N; R: 23/24/25-36-43-50/53; S: (1/2)-28-36/37-45-60-61 
UN Classification
UN Hazard Class: 6.1; UN Pack Group: III 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-61GT2-III.  Separated from food and feedstuffs. 

IMPORTANT DATA
Physical State; Appearance
WHITE-TO-SLIGHTLY-REDDISH CRYSTALS. 

Physical dangers
Dust explosion possible if in powder or granular form, mixed with air. 

Chemical dangers
Decomposes on heating. This produces toxic and corrosive fumes of of nitrogen oxides and hydrogen chloride. 

Occupational exposure limits
MAK (inhalable fraction): 0.1 mg/m³; Carcinogen category: 3B; Peak limitation category: II(2); Pregnancy risk group: D; Skin absorption (H); Sensitization of skin (SH); (DFG 2005). 

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion. 

Inhalation risk
Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed. 

Effects of short-term exposure
The substance is irritating to the eyes. The substance may cause effects on the blood and kidneys. This may result in formation of methaemoglobin and kidney impairment. Medical observation is indicated. The effects may be delayed. 

Effects of long-term or repeated exposure
Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Melting point: 275°C
Solubility in water: very good
Relative vapour density (air = 1): 6.2  
 

NOTES
Depending on the degree of exposure, periodic medical examination is indicated.
The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort.
Rest and medical observation are therefore essential.
Anyone who has shown symptoms of asthma due to this substance should never again come into contact with this substance.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
Also consult ICSC # 0805: Phenylenediamine.
Card has been partly updated in October 2005 and August 2006: see sections Emergency Response, Occupational Exposure Limits. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations