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TEMEPHOS
ICSC: 0199
Peer-Review Status: 17.04.2007 Validated
O,O,O',O'-Tetramethyl O,O'-thiodi-p-phenylene bis(phosphorothioate)
O,O'-(Thiodi-4,1-phenylene) bis(O,O-dimethylphosphorothioate)
Phosphorothioic acid, O,O'-(thiodi-4,1-phenylene) O,O,O',O'-tetramethyl ester 
CAS #: 3383-96-8 RTECS #: TF6890000
UN #: 2783
EINECS #: 222-191-1
    Formula: C16H20O6P2S3
Molecular mass: 466.5

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames.  Use water spray, foam, powder, carbon dioxide. 
EXPLOSION     In case of fire: keep drums, etc., cool by spraying with water. 
 
EXPOSURE   PREVENT DISPERSION OF DUST! PREVENT GENERATION OF MISTS!   
Inhalation Dizziness. Nausea. Muscle twitching. Sweating. Pupillary constriction, muscle cramp, excessive salivation. Vomiting. Diarrhoea. Laboured breathing. Convulsions. Unconciousness.  Use ventilation (not if powder), local exhaust or breathing protection.  Fresh air, rest. Refer for medical attention. 
Skin MAY BE ABSORBED! Further see Inhalation.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer immediately for medical attention. 
Eyes Blurred vision.  Wear face shield or eye protection in combination with breathing protection.  Rinse with plenty of water for several minutes (remove contact lenses if easily possible). Refer for medical attention. 
Ingestion Abdominal cramps. See Inhalation.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.  Do not transport with food and feedstuffs.
Marine pollutant. 
EC Classification
 
UN Classification
UN Hazard Class: 6.1; UN Pack Group: III 
GHS Classification
Signal: Danger
Toxic in contact with skin
Harmful if swallowed
Harmful if inhaled
Causes damage to nervous system
Very toxic to aquatic life
Very toxic to aquatic life with long lasting effects 
skull;toxiccancer;health hazenviro;aqua

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-61GT7-III.  Provision to contain effluent from fire extinguishing. Separated from food and feedstuffs. Well closed. Store in an area without drain or sewer access. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS OR WHITE CRYSTALS OR LIQUID. 

Physical dangers
 

Chemical dangers
Decomposes on heating and on burning. This produces toxic fumes including phosphorus oxides and sulfur oxides. 

Occupational exposure limits
TLV (inhalable fraction and vapour): 1mg/m³ as TWA; (skin); A4 (not classifiable as a human carcinogen); BEI issued; (ACGIH 2006). 

Routes of exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion. 

Inhalation risk
A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20°C. 

Effects of short-term exposure
Cholinesterase inhibition. The substance may cause effects on the nervous system. This may result in convulsions and respiratory depression. The effects may be delayed. Medical observation is indicated. Exposure far above the OEL could cause death. 

Effects of long-term or repeated exposure
Cholinesterase inhibition. Cumulative effects are possible. See Acute Hazards/Symptoms. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Decomposes at 120-125°C
Melting point: 30°C
Density: 1.3 g/cm³
Solubility in water: none
Vapour pressure at at 25°C°C: negligible
Octanol/water partition coefficient as log Pow: 5.96  
The substance is very toxic to aquatic organisms. This substance may be hazardous to the environment. Special attention should be given to bees. Bioaccumulation of this chemical may occur along the food chain. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal. 

NOTES
Depending on the degree of exposure, periodic medical examination is suggested.
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
Carrier solvents used in commercial formulations may change physical and toxicological properties.
The technical grade (90-95%) is a brown, viscous liquid.
Abate, Abathion, Swebate, Nimitex and Biothion are trade names. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations