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GLYCIDOL
ICSC: 0159
Peer-Review Status: 18.10.2005 Validated
2,3-Epoxy-1-propanol
Oxirane methanol
3-Hydroxypropylene oxide 
CAS #: 556-52-5 RTECS #: UB4375000
UN #: 2810
EC #: 603-063-00-8
EINECS #: 209-128-3
    Formula: C3H6O2
Molecular mass: 74.1

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Combustible.  NO open flames. NO contact with incompatible substances. See Chemical Dangers.  Use water spray, powder, alcohol-resistant foam, carbon dioxide. 
EXPLOSION Above 72°C explosive vapour/air mixtures may be formed.  Above 72°C use a closed system and ventilation.  In case of fire: keep drums, etc., cool by spraying with water. 
 
EXPOSURE   AVOID ALL CONTACT! AVOID EXPOSURE OF (PREGNANT) WOMEN!   
Inhalation Cough. Sore throat. Dizziness. Drowsiness.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Refer for medical attention. 
Skin MAY BE ABSORBED! Redness.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse skin with plenty of water or shower. 
Eyes Redness. Pain.  Wear face shield or eye protection in combination with breathing protection.  First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. 
Ingestion Abdominal pain. Diarrhoea. Nausea. Vomiting.  Do not eat, drink, or smoke during work. Wash hands before eating.  Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention . 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Personal protection: chemical protection suit including self-contained breathing apparatus. Collect leaking and spilled liquid in sealable glass or mild steel containers as far as possible. Absorb remaining liquid in dry sand or inert absorbent. Then store and dispose of according to local regulations.  Do not transport with food and feedstuffs. 
EC Classification
Symbol: T; R: 45-60-21/22-23-36/37/38-68; S: 53-45 
UN Classification
UN Hazard Class: 6.1; UN Pack Group: III 
GHS Classification
 

EMERGENCY RESPONSE SAFE STORAGE
Transport Emergency Card: TEC (R)-61GT1-III.  Store only if stabilized. Cool. Dry. Well closed. Ventilation along the floor. Separated from strong bases, strong acids and food and feedstuffs. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS SLIGHTLY VISCOUS LIQUID. 

Physical dangers
 

Chemical dangers
The substance may polymerize. Decomposes on contact with strong acids, strong bases, metal salts or metals. This generates fire and explosion hazard. Attacks plastics and rubber. 

Occupational exposure limits
TLV: 2ppm as TWA; A3 (confirmed animal carcinogen with unknown relevance to humans); (ACGIH 2005).
MAK: Carcinogen category: 2; Skin absorption (H); (DFG 2005). 

Routes of exposure
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. 

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C. 

Effects of short-term exposure
The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system. Exposure far above the OEL could cause lowering of consciousness. 

Effects of long-term or repeated exposure
This substance is probably carcinogenic to humans. Animal tests show that this substance possibly causes toxicity to human reproduction or development. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Decomposes at 166°C
Melting point: -45°C
Relative density (water = 1): 1.1
Solubility in water: miscible
Vapour pressure, Pa at 25°C: 120
Relative vapour density (air = 1): 2.15
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.0
Flash point: 72°C c.c.
Auto-ignition temperature: 415°C
Octanol/water partition coefficient as log Pow: -0.95  
 

NOTES
Depending on the degree of exposure, periodic medical examination is suggested.
Environmental effects from the substance have not been investigated adequately.
Other CAS numbers for the optical active forms are: d-Glycidol CAS 57044-25-4, l-Glycidol CAS 60456-23-7, dl-Glycidol CAS 61915-27-3. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.


    See Also:
       Toxicological Abbreviations
       Glycidol  (IARC Summary & Evaluation, Volume 77, 2000)