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CHLOROPRENE
ICSC: 0133
Peer-Review Status: 01.04.2009 Validated
2-Chloro-1,3-butadiene
2-Chlorobutadiene
beta-Chloroprene 
CAS #: 126-99-8 RTECS #: EI9625000
UN #: 1991 (inhibited)
EC #: 602-036-00-8
EINECS #: 204-818-0
    Formula: C4H5Cl / CH2=CClCH=CH2
Molecular mass: 88.5

TYPES OF
HAZARD /
EXPOSURE
ACUTE HAZARDS / SYMPTOMS      PREVENTION      FIRST AID / FIRE FIGHTING
FIRE Highly flammable. Many reactions may cause fire or explosion. Gives off irritating or toxic fumes (or gases) in a fire.  NO open flames, NO sparks and NO smoking.  Use powder, water spray, foam, carbon dioxide. 
EXPLOSION Vapour/air mixtures are explosive.  Closed system, ventilation, explosion-proof electrical equipment and lighting. Prevent build-up of electrostatic charges (e.g., by grounding). Use non-sparking handtools.  In case of fire: keep drums, etc., cool by spraying with water. 
 
EXPOSURE   STRICT HYGIENE!  IN ALL CASES CONSULT A DOCTOR! 
Inhalation Cough. Sore throat. Headache. Dizziness. Drowsiness. Laboured breathing. Heart palpitations. Unconciousness.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Half-upright position. Refer immediately for medical attention. 
Skin MAY BE ABSORBED! Redness. Pain. Burning sensation. See Inhalation.  Protective gloves. Protective clothing.  Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer immediately for medical attention. 
Eyes Redness. Pain. Corneal damage.  Wear safety goggles, face shield or eye protection in combination with breathing protection.  Rinse with plenty of water (remove contact lenses if easily possible). Refer for medical attention. 
Ingestion See Inhalation.  Do not eat, drink, or smoke during work.  Rinse mouth. Do NOT induce vomiting. Refer immediately for medical attention. 

SPILLAGE DISPOSAL
PACKAGING & LABELLING
Remove all ignition sources. Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT wash away into sewer.  Airtight.
Unbreakable packaging.
Put breakable packaging into closed unbreakable container.
Do not transport with food and feedstuffs. 
EC Classification
Symbol: F, T; R: 45-11-20/22-36/37/38-48/20; S: 53-45; Note: D, E 
UN Classification
UN Hazard Class: 3; UN Subsidiary Risks: 6.1; UN Pack Group: I 
GHS Classification
Signal: Danger
Highly flammable liquid and vapour
Toxic if swallowed
Causes skin irritation
Causes serious eye irritation
Suspected of causing cancer
Causes damage to organs
May cause damage to organs through prolonged or repeated exposure 
flam;flameskull;toxiccancer;health haz

EMERGENCY RESPONSE SAFE STORAGE
NFPA Code: H2; F3; R1.  Fireproof. Separated from food and feedstuffs and incompatible materials. See Chemical Dangers. Cool. Keep in the dark. Well closed. Store only if stabilized. Store in an area without drain or sewer access. 

IMPORTANT DATA
Physical State; Appearance
COLOURLESS LIQUID WITH PUNGENT ODOUR. 

Physical dangers
The vapour is heavier than air and may travel along the ground; distant ignition possible. As a result of flow, agitation, etc., electrostatic charges can be generated. 

Chemical dangers
The substance can readily form explosive peroxides under specific circumstances, initiating explosive polymerization. The substance may polymerize if it is not stabilized. This generates fire or explosion hazard. On combustion, forms toxic and corrosive gases including phosgene (see ICSC 0007) and hydrogen chloride (see ICSC 0163). Reacts with oxidants and powdered metals. This generates fire and explosion hazard. 

Occupational exposure limits
TLV: 10ppm, 36mg/m³ as TWA; (skin); (ACGIH 2009).
MAK: Carcinogen category: 2; Skin absorption (H); (DFG 2008). 

Routes of exposure
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. 

Inhalation risk
A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20°C. 

Effects of short-term exposure
The substance is severely irritating to the eyes. The substance is irritating to the skin and respiratory tract. Exposure at high levels could cause lung oedema. The substance may cause effects on several organs. This may result in impaired functions. Exposure above the OEL could cause death. 

Effects of long-term or repeated exposure
Repeated or prolonged contact with skin may cause dermatitis and hair loss. The substance may have effects on multiple organs. This may result in impaired functions. This substance is possibly carcinogenic to humans. 


PHYSICAL PROPERTIES ENVIRONMENTAL DATA
Boiling point: 59.4°C
Melting point: -130°C
Relative density (water = 1): 0.96
Solubility in water, g/100ml at 20°C: 0.03 (very poor)
Vapour pressure, kPa at 20°C: 23.2
Relative vapour density (air = 1): 3.1
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.5
Flash point: -20°C c.c.
Auto-ignition temperature: 440°C
Explosive limits, vol% in air: 1.9-20
Octanol/water partition coefficient as log Pow: 2.2 (calculated) 
 

NOTES
An added stabilizer or inhibitor can influence the toxicological properties of this substance; consult an expert.
The odour warning when the exposure limit value is exceeded is insufficient.
Do NOT use in the vicinity of a fire or a hot surface, or during welding.
Check for peroxides prior to distillation; eliminate if found.
Inhibitors such as hydroquinone or phenothiazine are generally added when it is to be stored.
Do NOT take working clothes home. 

ADDITIONAL INFORMATION
 

IPCS
International
Programme on
Chemical Safety
WHO ILO EC Prepared in the context of cooperation between the International Programme on Chemical Safety and the European Commission
© IPCS 2004-2012
LEGAL NOTICE Neither the EC nor the IPCS nor any person acting on behalf of the EC or the IPCS is responsible for the use which might be made of this information.
    See Also:
       Toxicological Abbreviations
       Chloroprene  (SIDS)
       Chloroprene (IARC Summary & Evaluation, Volume 71, 1999)