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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

BENZYL ACETATE
(Group 3)

For definition of Groups, see Preamble Evaluation.

VOL.: 71 (1999) (p. 1255)

CAS No.: 140-11-4

5. Summary of Data Reported and Evaluation

5.1 Exposure data

There is widespread human exposure to benzyl acetate by ingestion, skin application and inhalation.

5.2 Human carcinogenicity data

No data were available to the Working Group.

5.3 Animal carcinogenicity data

Benzyl acetate was tested for carcinogenicity by gavage in one experiment in mice and in one experiment in rats, and by administration in the diet in two studies in rats and in one study in mice. In the gavage study in mice, increased incidences of liver adenomas and of combined liver adenomas and carcinomas were oberved in animals of each sex. An increased incidence of forestomach tumours was observed in mice of each sex. An increased incidence of acinar-cell adenomas of the pancreas was observed in male rats administered benzyl acetate by gavage. Benzyl acetate did not increase the incidence of tumours in either mice or rats when administered in the diet. A low incidence of pancreatic carcinomas in situ was reported in one study.

Benzyl acetate was tested in two studies for promotion of pancreatic carcinogenesis in rats and was found to be inactive.

5.4 Other relevant data

Benzyl acetate is hydrolysed to benzoic acid and acetate. It is metabolized similarly by humans and rodents. Except for one positive result in vitro, findings on genotoxicity in vitro and in vivo were negative.

5.5 Evaluation

No epidemiological data relevant to the carcinogenicity of benzyl acetate were available.

There is limited evidence in experimental animals for the carcinogenicity of benzyl acetate.

Overall evaluation

Benzyl acetate is not classifiable as to its carcinogenicity to humans (Group 3).

For definition of the italicized terms, see Preamble Evaluation.

Previous evaluation: Vol. 40 (1986)

Synonym


Last updated: 13 April 1999





















    See Also:
       Toxicological Abbreviations
       Benzyl acetate (ICSC)
       Benzyl acetate (FAO Nutrition Meetings Report Series 44a)
       Benzyl acetate (WHO Food Additives Series 26)
       Benzyl acetate (WHO Food Additives Series 32)
       Benzyl acetate (WHO Food Additives Series 37)
       BENZYL ACETATE (JECFA Evaluation)
       Benzyl Acetate  (IARC Summary & Evaluation, Volume 40, 1986)