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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

CI ACID RED 114
(Group 2B)


For definition of Groups, see Preamble Evaluation.

VOL.: 57 (1993) (p. 247)
CAS No.: 6459-94-5
Chem. Abstr. Name: 8-[(3,3'-Dimethyl-4'-[(4-[([4-methylphenyl]sulfonyl)oxy]phenyl)azo][1,1'-biphenyl]-4-yl)azo]-7-hydroxy-
1,3-naphthalenedisulfonic acid, disodium salt

5. Summary of Data Reported and Evaluation

5.1 Exposure data

CI Acid Red 114, a bis-azo dye derived from 3,3'-dimethylbenzidine, is used to dye wool, silk, jute and leather.

5.2 Human carcinogenicity data

No data were available to the Working Group.

5.3 Animal carcinogenicity data

CI Acid Red 114 was tested for carcinogenicity in one study in rats by administration in the drinking-water. It increased the incidences of benign and malignant tumours of the skin, Zymbal gland and liver in male and female rats, and of the clitoral gland, lung, oral cavity and small and large intestine in female rats.

5.4 Other relevant data

Reductive cleavage of the azo bonds to yield 3,3'-dimethylbenzidine was demonstrated in vivo.

CI Acid Red 114 induced gene mutation in bacteria under reducing conditions. It did not induce gene mutation in insects or sister chromatid exchange or chromosomal aberrations in cultured mammalian cells.

5.5 Evaluation

There is inadequate evidence in humans for the carcinogenicity of CI Acid Red 114.

There is sufficient evidence in experimental animals for the carcinogenicity of CI Acid Red 114.

Overall evaluation

CI Acid Red 114 is possibly carcinogenic to humans (Group 2B).

For definition of the italicized terms, see Preamble Evaluation.

Synonyms


Last updated 08/22/1997






















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       Toxicological Abbreviations