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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

HC BLUE No. 2
(Group 3)

For definition of Groups, see Preamble Evaluation.

VOL.: 57 (1993) (p. 143)
CAS No.: 33229-34-4
Chem. Abstr. Name: 2,2'-([4-([2-Hydroxyethyl]amino)-3-nitrophenyl]imino)bis(ethanol)

5. Summary of Data Reported and Evaluation

5.1 Exposure data

HC Blue No. 2 is used as a semi-permanent hair dye.

5.2 Human carcinogenicity data

No data were available to the Working Group.

5.3 Animal carcinogenicity data

HC Blue No. 2 was tested for carcinogenicity by administration in the diet in one study in mice and in one study in rats. No significant increase in tumour incidence was observed in either species, but the data on female mice could not be adequately evaluated.

5.4 Other relevant data

HC Blue No. 2 induced gene mutation in bacteria. It induced DNA damage, gene mutation and sister chromatid exchange but not chromosomal aberrations or inhibition of intercellular communication in cultured mammalian cells. Micronuclei were not induced in the bone marrow of mice exposed in vivo.

5.5 Evaluation

There is inadequate evidence in humans for the carcinogenicity of HC Blue No. 2.

There is inadequate evidence in experimental animals for the carcinogenicity of HC Blue No. 2.

Overall evaluation

HC Blue No. 2 is not classifiable as to its carcinogenicity to humans (Group 3).

For definition of the italicized terms, see Preamble Evaluation.

Synonyms


Last updated 08/22/1997






















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