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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

6-NITROCHRYSENE
(Group 2B)

For definition of Groups, see Preamble Evaluation.

VOL.: 46 (1989) (p. 267)

CAS No.: 7496-02-8
Chem. Abstr. Name: Chrysene, 6-nitro

5. Summary of Data Reported and Evaluation

5.1 Exposure data

6-Nitrochrysene was found in ambient air at a low concentration in one study.

5.2 Experimental data

6-Nitrochrysene was tested for initiating activity on mouse skin and was found to be active. It was also tested for carcinogenicity in two experiments by intraperitoneal injection into newborn mice, producing increased incidences of lung and liver-cell tumours and of malignant lymphomas.

5.3 Human data

No data were available to the Working Group.

5.4 Other relevant data

Intraperitoneal injection of 6-nitrochrysene caused a substantial increase in aryl hydrocarbon hydroxylase activity in rat liver. Metabolism of 6-nitrochrysene led to DNA adduct formation in cultured mammalian cells and in animals. 6-Nitrochrysene caused transformation in cultured animal cells. It was mutagenic to and induced DNA damage in bacteria.

5.5 Evaluation

There is sufficient evidence for the carcinogenicity in experimental animals of 6-nitrochrysene.

No data were available from studies in humans on the carcinogenicity of 6-nitrochrysene.

Overall evaluation

6-Nitrochrysene is possibly carcinogenic to humans (Group 2B).

For definition of the italicized terms, see Preamble Evaluation.

Previous evaluations: Vol. 33 (1984) (p. 195); Suppl. 7 (1987) (p. 67)


Last updated 01/21/98























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