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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

7-NITROBENZ[a]ANTHRACENE
(Group 3)

For definition of Groups, see Preamble Evaluation.

VOL.: 46 (1989) (p. 247)

CAS No.: 20268-51-3
Chem. Abstr. Name: Benz[a]anthracene, 7-nitro-

5. Summary of Data Reported and Evaluation

5.1 Exposure data

No data were available to the Working Group.

5.2 Experimental data

7-Nitrobenz[a]anthracene was tested for carcinogenicity in one experiment by intraperitoneal injection into newborn mice, resulting in an increased incidence of liver-cell tumours in males.

5.3 Human data

No data were available to the Working Group.

5.4 Other relevant data

Metabolism of 7-nitrobenz[a]anthracene led to binding to exogenous DNA. It was not mutagenic to bacteria.

5.5 Evaluation

There is limited evidence for the carcinogenicity in experimental animals of 7-nitrobenz[a]anthracene.

No data were available from studies in humans on the carcinogenicity of 7-nitrobenz[a]anthracene.

Overall evaluation

7-Nitrobenz[a]anthracene is not classifiable as to its carcinogenicity to humans (Group 3).

For definition of the italicized terms, see Preamble Evaluation.


Last updated 01/21/98























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