International Agency for Research on Cancer (IARC) - Summaries & Evaluations
BIS(2-CHLORO-1-METHYLETHYL)ETHER
VOL.: 41 (1986) (p. 149)
CAS No.: 108-60-1
Chem. Abstr. Name: 2,2'-Oxybis(1-chloropropane)
5. Summary of Data Reported and Evaluation
5.1 Exposure data
Bis(2-chloro-1-methylethyl)ether has been produced as a solvent and
soil fumigant and is also formed in large quantities as a by-product
in some propylene oxide/propylene glycol production processes. Low
levels have been found in water. Thus, both occupational and
environmental exposures may occur.
5.2 Experimental data
Bis(2-chloro-1-methylethyl)ether, containing
2-chloro-1-methylethyl(2-chloro-n-propyl)ether and
bis(2-chloro-n-propyl)ether, was tested for carcinogenicity by oral
administration by gavage in one experiment in mice and in one
experiment in rats. In mice, increased incidences of lung adenomas in
males and females and of hepatocellular carcinomas in males were
observed. In rats, no increase in tumour incidence was observed.
No data were available to evaluate the reproductive or prenatal
effects of bis(2-chloro-1-methylethyl)ether to experimental animals.
Bis(2-chloro-1-methylethyl)ether is mutagenic to Salmonella
typhimurium. It does not induce sex-linked recessive lethal mutations
in Drosophila melanogaster.
4.3 Human data
No data were available to evaluate the reproductive effects or
prenatal toxicity of bis(2-chloro-1-methylethyl)ether to humans.
No case report or epidemiological study of the carcinogenicity of
bis(2-chloro-1-methylethyl)ether to humans was available to the
Working Group.
4.4 Evaluation
There is limited evidence for the carcinogenicity of
bis(2-chloro-1-methylethyl)ether to experimental animals.
No evaluation could be made of the carcinogenicity of
bis(2-chloro-1-methylethyl)ether to humans.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Vol. 71 (1999)
Synonyms
- BCMEE
- Bis(b-chloroisopropyl)ether
- Bis(2-chloroisopropyl)ether
- Bis(2-chloro-2-methylethyl)ether
- Bis(1-chloro-2-propyl) ether
- DCIP
- Dichlorodiisopropyl ether
- 2,2'-Dichlorodiisopropyl ether
- b,b'-Dichlorodiispropyl ether
- Dichloroisopropylether
- 2,2'-Oxybis(2-chloropropane)
Last updated: 13 April 1999