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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

3,3'-DIMETHOXYBENZIDINE-4,4'-DIISOCYANATE

VOL.: 39 (1986) (p. 279)

CAS No.: 91-93-0
Chem. Abstr. Name: 1,1'-Biphenyl, 4,4'-diisocyanato-3,3'-

5. Summary of Data Reported and Evaluation

5.1 Exposure data

3,3'-Dimethoxybenzidine-4,4'-diisocyanate has been used in isocyanate-based adhesives and as a components of polyurethane elastomers. There is no evidence of current exposure.

5.2 Experimental data

3,3'-Dimethoxybenzidine-4,4'-diisocyanate was tested for carcinogenicity in one study in mice by administration in the diet and in one study in rats by gavage followed by dietary administration. No treatment-related tumour was observed in mice. A statistically significant increase in the combined incidence of leukaemia and malignant lymphomas was observed in both male and female rats, together with a treatment-related increase in the incidence of tumours of the skin and Zymbal gland. Increases in the incidence of endometrial stromal polyps were observed in female rats.

No data were available to evaluate the reproductive effects or prenatal toxicity of 3,3'-dimethoxybenzidine-4,4'-diisocyanate to experimental animals.

3,3'-Dimethoxybenzidine-4,4'-diisocyanate was mutagenic to Salmonella typhimurium in the presence of an exogenous metabolic system.

5.3 Human data

No data were available to evaluate the reproductive effects or prenatal toxicity of 3,3'-dimethoxybenzidine-4,4'-diisocyanate to humans.

No case report or epidemiological study was available to evaluate the carcinogenicity of 3,3'-dimethoxybenzidine-4,4'-diisocyanate to humans.

5.4 Evaluation

There is limited evidence for the carcinogenicity of 3,3'-dimethoxybenzidine-4,4'-diisocyanate to experimental animals.

No data on humans were available.

In the absence of epidemiological data, no evaluation of the carcinogenicity of 3,3'-dimethoxybenzidine-4,4'-diisocyanate to humans could be made.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 62: Group 3)

Synonyms


Last updated: 21 April 1998






















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