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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

4,4'-METHYLENEDIANILINE AND ITS DIHYDROCHLORIDE

VOL.: 39 (1986) (p. 347)

4,4'-Methylenedianiline
CAS No.: 101-77-9
Chem. Abstr. Name: Benzenamine, 4,4'-methylenebis-

4,4'-Methylenedianiline dihydrochloride
CAS No.: 13552-44-8
Chem. Abstr. Name: Benzenamine, 4,4'-methylenebis-, dihydrochloride

5. Summary of Data Reported and Evaluation

5.1 Exposure data

4,4'-Methylenedianiline has been available commercially since the 1920s. It is used mainly as an intermediate in 4,4'-methylenediphenyl diisocyanate production and as a curing agent for epoxy resins. Exposure occurs during the production of 4,4'-methylenedianiline and the use of 4,4'-methylenediphenyl diisocyanate resins.

5.2 Experimental data

4,4'-Methylenedianiline and its dihydrochloride were tested for carcinogenicity by oral administration in mice, rats and dogs. Treatment-related increases in the incidences of thyroid follicular-cell adenomas and hepatocellular neoplasms were observed in both male and female mice. In rats, treatment-related increases in the incidences of thyroid follicular-cell carcinomas and hepatic nodules were observed in males and thyroid follicular-cell adenomas occurred in females. In a study in rats in which 4,4'-methylenedianiline was administered orally in conjunction with a known carcinogen, the incidence of thyroid tumours was greater than that produced by the carcinogen alone.

The available data were inadequate to evaluate the reproductive effects or prenatal toxicity of 4,4'-methylenedianiline to experimental animals.

4,4'-Methylenedianiline was mutagenic to Salmonella typhimurium in the presence of an exogenous metabolic system. It induced DNA damage in Chinese hamster V79 cells in the presence of an exogenous metabolic system, and induced DNA damage in the liver of rats and sister chromatid exchange in the bone marrow of mice treated in vivo.

5.3 Human data

4,4'-Methylenedianiline is hepatotoxic. No data were available to evaluate the reproductive effects or prenatal toxicity of 4,4'-methylenedianiline to humans.

No case report or epidemiological study was available to evaluate the carcinogenicity of 4,4'-methylenedianiline to humans.

5.4 Evaluation

There is sufficient evidence for the carcinogenicity of 4,4'-methylenedianiline and its dihydrochloride to experimental animals.

No data on humans were available.

For definition of the italicized terms, see Preamble Evaluation.

Previous evaluation: Vol. 4 (1974)

Subsequent evaluation: Suppl. 7 (1987) (p. 66: Group 2B)

Synonyms

Synonym


Last updated: 21 April 1998






















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