International Agency for Research on Cancer (IARC) - Summaries & Evaluations
11-AMINOUNDECANOIC ACID
VOL.: 39 (1986) (p. 239)
CAS No.: 2432-99-7
Chem. Abstr. Name: Undecanoic acid, 11-amino-
5. Summary of Data Reported and Evaluation
5.1 Exposure data
11-Aminoundecanoic acid is synthesized by one company for the
production of Nylon 11.
5.2 Experimental data
11-Aminoundecanoic acid was tested for carcinogenicity in mice
and rats by administration in the diet. Increased incidences of
transitional-cell carcinomas of the urinary bladder and neoplastic
nodules of the liver were observed in male rats. Transitional-cell
carcinomas of the kidney and epithelial hyperplasia of the urinary
bladder and renal pelvis were observed in male and female rats. No
clear evidence for an increased incidence of treatment-related tumours
was seen in mice.
No data were available to evaluate the reproductive effects or
prenatal toxicity of 11-aminoundecanoic acid to experimental animals.
11-Aminodecanoic acid was not mutagenic to Drosophila melanogaster.
5.3 Human data
No data were available to evaluate the reproductive effects or
prenatal toxicity of 11-aminoundecanoic acid to humans.
No case report or epidemiological study was available to evaluate
the carcinogenicity of 11-aminoundecanoic acid to humans.
5.4 Evaluation
There is limited evidence for the carcinogenicity of
11-aminoundecanoic acid in experimental animals.
No data on humans were available.
In the absence of epidemiological data, no evaluation of the
carcinogenicity of 11-aminoundecanoic acid to humans could be made.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 57: Group 3)
Synonyms
- Aminoundecanoic acid
- l-Aminoundecanoic acid
- 11-Aminoundecylic acid
Last updated: 21 April 1998