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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

4-(METHYLNITROSAMINO)-4-(3-PYRIDYL)BUTANAL (NNA)

VOL.: 37 (1985) (p. 205)

CAS No.: 64091-90-3
Chem. Abstr. Name: 3-Pyridinebutanal, g-(methylnitrosoamino)-

5. Summary of Data Reported and Evaluation

5.1 Exposures

No analytical evidence was found that 4-(methylnitrosamino)-4-(3-pyridyl)butanal (NNA) occurs in tobacco or in the saliva of snuff users, although, under certain laboratory conditions, its formation from nicotine has been observed.

5.2 Experimental data

NNA was tested by intraperitoneal injection in female mice of one strain at one dose level only. Although the incidence of lung adenomas in treated mice exceeded those in controls, the experiment does not allow an evaluation of the carcinogenicity of NNA.

No data were available on mutagenic or related effects of NNA.

5.3 Human data

No case report or epidemiological study of the carcinogenicity of NNA to humans was available to the Working Group.

5.4 Evaluation

The available data are inadequate to evaluate the carcinogenicity of 4-(methylnitrosamino)-4-
(3-pyridyl)butanol to experimental animals.

No data on humans were available.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 68: Group 3)

Synonym


Last updated: 21 April 1998






















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