VOL.: 37 (1985) (p. 263)
Chem. Abstr. Name: 3-Methylnitrosaminopropionaldehyde (MNPA)
Chem. Abstr. Name: 3-Methylnitrosaminopropionitrile (MNPN)
Chem. Abstr. Name: N-Nitrosoguvacine (NGC)
Chem. Abstr. Name: N-Nitrosoguvacoline (NGL)
3-Methylnitrosaminopropionitrile was tested in one 24-week experiment in rats by subcutaneous injection. Within this short period, it produced multiple papillomas and carcinomas of the oesophagus and tongue, and papillomas of the nasal cavity.
No data were available to evaluate the carcinogenicity of
N-nitrosoguvacine or 3-methylnitrosamino-
propionaldehyde to experimental animals.
The one available study was inadequate to evaluate the mutagenicity of N-nitrosoguvacine to Salmonella typhimurium.
N-Nitrosoguvacoline was mutagenic to Salmonella typhimurium in the presence of a metabolic system. It did not induce sex-linked recessive lethal mutations in Drosophila melanogaster.
No data were available to assess the mutagenic or related effects of 3-methylnitrosaminopropionitrile or 3-methylnitrosaminopropionaldehyde.
No data on humans were available.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 68: 3-methylnitrosaminopropionaldehyde (MNPA) - Group 3; 3-methylnitrosaminopropionitrile (MNPN) - Group 2B; N-nitrosoguvacine (NGC) - Group 3; N-nitrosoguvacoline (NGL) - Group 3)
See Also: Toxicological Abbreviations