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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

SOME N-NITROSAMINES DERIVED FROM ARECA-NUT ALKALOIDS

VOL.: 37 (1985) (p. 263)

CAS No.: 85502-23-4
Chem. Abstr. Name: 3-Methylnitrosaminopropionaldehyde (MNPA)

CAS No.: 60153-49-3
Chem. Abstr. Name: 3-Methylnitrosaminopropionitrile (MNPN)

CAS No.: 55557-01-2
Chem. Abstr. Name: N-Nitrosoguvacine (NGC)

CAS No.: 55557-02-3
Chem. Abstr. Name: N-Nitrosoguvacoline (NGL)

5. Summary of Data Reported and Evaluation

5.1 Exposures

N-Nitrosoguvacoline and N-nitrosoguvacine have been found in the saliva of betel-quid chewers. Thus, there is some evidence that chewers are exposed to these compounds.

5.2 Experimental data

N-Nitrosoguvacoline was tested in one experiment in rats by administration in drinking-water. Although no increase in the incidence of tumours was detected, the experiment was not adequate to allow an evaluation of its carcinogenicity.

3-Methylnitrosaminopropionitrile was tested in one 24-week experiment in rats by subcutaneous injection. Within this short period, it produced multiple papillomas and carcinomas of the oesophagus and tongue, and papillomas of the nasal cavity.

No data were available to evaluate the carcinogenicity of N-nitrosoguvacine or 3-methylnitrosamino-
propionaldehyde to experimental animals.

The one available study was inadequate to evaluate the mutagenicity of N-nitrosoguvacine to Salmonella typhimurium.

N-Nitrosoguvacoline was mutagenic to Salmonella typhimurium in the presence of a metabolic system. It did not induce sex-linked recessive lethal mutations in Drosophila melanogaster.

No data were available to assess the mutagenic or related effects of 3-methylnitrosaminopropionitrile or 3-methylnitrosaminopropionaldehyde.

5.3 Human data

No case report or epidemiological study of the carcinogenicity of these compounds to humans was available to the Working Group.

5.4 Evaluation

There is sufficient evidence for the carcinogenicity of 3-methylnitrosaminopropionitrile to experimental animals. There is inadequate evidence to evaluate the carcinogenicity of N-nitrosoguvacoline to experimental animals. No data were available to assess the carcinogenicity of N-nitrosoguvacine or 3-methylnitrosaminopropionaldehyde to experimental animals.

No data on humans were available.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 68: 3-methylnitrosaminopropionaldehyde (MNPA) - Group 3; 3-methylnitrosaminopropionitrile (MNPN) - Group 2B; N-nitrosoguvacine (NGC) - Group 3; N-nitrosoguvacoline (NGL) - Group 3)

Synonyms


Last updated: 21 April 1998






















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       Toxicological Abbreviations