VOL.: 32 (1983) (p. 431)
A study in mice by subcutaneous injection was inadequate for evaluation of carcinogenicity.
Intratracheal administration to hamsters of pyrene attached to haematite did not produce tumours.
No data on the teratogenicity of this compound were available.
Pyrene has been tested extensively in both in-vitro and in-vivo short-term tests. It was negative in assays for differential survival in DNA-repair-proficient/-deficient strains of bacteria and was mutagenic in some assays in Salmonella typhimurium in the presence of an exogenous metabolic system. Tests for genetic activity in yeast were negative. It was not mutagenic to Drosophila melanogaster. It did induce mutations and unscheduled DNA synthesis in some in-vitro assays in mammalian cells. Pyrene did not induce morphological transformation. In tests in mammals in-vivo it did not induce sister chromatid exchange or micronuclei.
There is limited evidence that pyrene is active in short-term tests.
Subsequent evaluation: Suppl. 7 (1987) (p. 71: Group 3)
See Also: Toxicological Abbreviations Pyrene (ICSC)