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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

PERYLENE

VOL.: 32 (1983) (p. 411)

CAS No.: 198-55-0

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Perylene was tested for carcinogicity by skin application to mice in one experiment, and no carcinogenic effect was observed. It was also tested in the mouse-skin initiation-promotion assay in one study, with negative results.

No data on the teratogenicity of this compound were available.

Perylene was mutagenic to Salmonella typhimurium in the presence of an exogenous metabolic system. In one study, it did not induce mutations in cultured human lymphoblastoid cells. The data from one study on chromosomal effects were inadequate to make an evaluation.

There is inadequate evidence that perylene is active in short-term tests.

5.2 Human data

Perylene is present as a minor component of the total content of polynuclear aromatic compounds of the environment. Human exposure to perylene occurs primarily through the smoking of tobacco, inhalation of polluted air and by ingestion of food and water contaminated with combustion products.

5.3 Evaluation

The available data are inadequate to permit an evaluation of the carcinogenicity of perylene in experimental animals.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 69: Group 3)

Synonyms


Last updated: 17 April 1998






















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