VOL.: 32 (1983) (p. 299)
Chem. Abstr. Name: Dibenz(a,h)anthracene
Dibenz[a,h]anthracene is embryotoxic to rats when given at high doses. The available data on teratogenicity were inadequate for evaluation
Dibenz[a,h]anthracene was positive in differential survival assays using DNA-repair-proficient/-deficient strains of bacteria and was mutagenic to Salmonella typhimurium in the presence of an exogenous metabolic system. In cultured mammalian cells, dibenz[a,h]anthracene was mutagenic and induced unscheduled DNA synthesis in the presence of an exogenous metabolic system. It was positive in assays for morphological transformation. In the one available study, it induced sister chromatid exchange but not chromosomal aberrations in vivo.
There is sufficient evidence that dibenz[a,h]anthracene is active in short-term tests.
For definition of the italicized terms, see Preamble Evaluation.
Previous evaluation: Vol. 3 (1973)
Subsequent evaluation: Suppl. 7 (1987) (p. 58: Group 2A)
See Also: Toxicological Abbreviations