VOL.: 32 (1983) (p. 269)
Chem. Abstr. Name: Cyclopenta(cd)pyrene
No data were available on the teratogenicity of this chemical.
Cyclopenta[cd]pyrene was mutagenic to Salmonella typhimurium and to mammalian cells in vitro in the presence of an exogenous metabolic system. It induced morphological transformation in mammalian cells.
There is sufficient evidence that cyclopenta[cd]pyrene is active in short-term tests.
N.B. - Subsequent to the meeting, the Secretariat became aware of a study (Cavalieri et al., 1983) in which cyclopenta[cd]pyrene was tested alone or in combination with benzo[a]pyrene by repeated application to the skin of female Swiss mice. At the end of the experiment, analysis of the incidence of malignant skin tumours showed that the two compounds acted synergistically.
N.B. - Studies on occupational exposure to polynuclear aromatic compounds will be considered in future IARC Monographs.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 61: Group 3)
See Also: Toxicological Abbreviations