VOL.: 32 (1983) (p. 105)
It was tested in rats by oral, subcutaneous, intraperitoneal and intrapulmonary administration, and in rabbits by implantation into the brain or eyes. The studies involving oral or intrapulmonary administration produced no evidence of carcinogenicity. The studies in rats by subcutaneous or intraperitoneal administration and in rabbits by implantation into the brain or eyes were inadequate for evaluation.
When anthracene was administered by skin application to mice together with exposure to ultraviolet radiation, contradictory results were obtained.
No data on the teratogenicity of this compound were available.
Anthracene was negative in an assay for differential survival using DNA repair-proficient/-deficient strains of Bacillus subtilis. It did not induce mutations in bacteria or yeast nor unscheduled DNA synthesis or mutations in cultured mammalian cells. No cytogenetic effect in mammalian cells was observed in vitro or in vivo, and assays for morphological transformation were negative.
There is no evidence that anthracene is active in short-term tests.
No relevant case report or epidemiological study on exposure to anthracene alone was available to the Working Group.
Subsequent evaluation: Suppl. 7 (1987) (p. 57: Group 3)
See Also: Toxicological Abbreviations Anthracene (ICSC)