International Agency for Research on Cancer (IARC) - Summaries & Evaluations
AND ITS ACETATE
VOL.: 31 (1983) (p. 255)
CAS No.: 62450-07-1
Chem. Abstr. Name: 5H-Pyrido[4,3-b]indol-3-amine, 1-methyl-
Chem. Abstr. Name: 5H-Pyrido[4,3-b]indol-3-amine, 1-methyl-, monoacetate
5. Summary of Data Reported and Evaluation
5.1 Experimental data
Trp-P-2 was tested for carcinogenicity in mice and rats by
administration in the diet, in mice by skin application and bladder
implantation and in rats and hamsters by subcutaneous administration.
An increased incidence of liver tumours was observed in female mice
and female rats following its oral administration. Bladder carcinomas
were observed in female mice after implantation of Trp-P-2 in paraffin
pellets at this site. The results of the experiments by subcutaneous
injection and by skin application were considered inadequate for
Trp-P-2 is mutagenic to Salmonella typhimurium following
metabolic activation. It induced chromosomal anomalies in mammalian
cells, including human cells, in vitro. It caused neoplastic
transformation in vitro in Syrian golden hamster cells. There is
sufficient evidence that Trp-P-2 is active in short-term tests.
No data were available to evaluate the teratogenicity of this
compound to experimental animals.
5.2 Human data
Trp-P-2 is found in the charred fraction of cooked fish, and the
consumption of this food is a source of exposure for the general
No data were available to evaluate the teratogenicity or
chromosomal effects of this compound in humans.
No case report or epidemiological study of the carcinogenicity of
Trp-P-2 was available to the Working Group.
There is sufficient evidence for the carcinogenicity of Trp-P-2
in experimental animals. No data on humans were available.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 73: Group 2B)
Synonyms for Trp-P-2
- Tryptophan P2
Synonym for Trp-P-2 acetate
Last updated: 16 April 1998