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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

TRP-P-1 (3-AMINO-1,4-DIMETHYL-5H-PYRIDO[4,3-b]INDOLE)
AND ITS ACETATE

VOL.: 31 (1983) (p. 247)

Trp-P-1
CAS No.: 62450-06-0
Chem. Abstr. Name: 5H-Pyrido[4,3-b]indol-3-amine, 1,4-dimethyl-

Trp-P-1 acetate
CAS No.: 75104-43-7 (acetate); 68808-54-8 (monoacetate)
Chem. Abstr. Name: 5H-Pyrido[4,3-b]indol-3-amine, 1,4-dimethyl-, acetate; 5H-pyrido[4,3-b]indol-3-amine, 1,4-dimethyl-, monoacetate

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Trp-P-1 was tested for carcinogenicity in mice by administration in the diet, by skin application and by bladder implantation, and in rats and hamsters by subcutaneous administration. Hepatic tumours were induced by oral administration in both male and female mice, although the increased incidence was significant only in females. In female rats, there was a significant increase in the incidence of fibrosarcomas at the site of injection; in hamsters there was an increased incidence of subcutaneous sarcomas. Bladder carcinomas were observed in female mice after implantation of paraffin pellets containing Trp-P-1 at this site. The study in mice by skin painting was inadequate for evaluation.

Trp-P-1 is mutagenic to bacteria following metabolic activation. It induced chromosomal anomalies in mammalian cells, including human cells, in vitro. It also caused morphological transformation of hamster embryo cells. There is sufficient evidence that Trp-P-1 is active in short-term tests.

No data were available to evaluate the teratogenicity of this compound to experimental animals.

5.2 Human data

Trp-P-1 is found in the charred fraction of cooked fish and meat, and the consumption of these foods is a source of exposure for the general population.

No data were available to evaluate the teratogenicity or chromosomal effects of this compound in humans.

No case report or epidemiological study of the carcinogenicity of Trp-P-1 was available to the Working Group.

5.3 Evaluation

There is sufficient evidence for the carcinogenicity of Trp-P-1 in experimental animals. No data on humans were available.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 73: Group 2B)

Synonyms for Tr-P-1

Synonyms for Tr-P-1 acetate


Last updated: 16 April 1998






















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       Toxicological Abbreviations