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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

SYMPHYTINE

VOL.: 31 (1983) (p. 239)

CAS No.: 22571-95-5
Chem. Abstr. Name: 2-Butenoic acid, 2-methyl-, 7-[[2,3-dihydroxy- 2-(1-methylethyl)-1-
oxobutoxy]methyl]-2,3,5,7a-tetrahydro-1H- pyrrolizin-1-yl ester,[1R-[1a(E), 7(2S*,3S*),7ab]]-

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Symphytine was tested for carcinogenicity in male rats by intraperitoneal administration; a non-significant increase in the incidence of liver tumours was observed. When leaves and roots of Symphytum officinale L. were tested in rats by administration in the diet, the incidence of liver tumours was increased.

Symphytine was mutagenic in Salmonella typhimurium and in mammalian cells in vitro. The data were inadequate to evaluate the activity of symphytine in short-term tests.

No data were available to evaluate the teratogenicity of this compound to experimental animals.

5.2 Human data

Symphytine is found in several plant species which are used as foods and as herbal remedies, resulting in wide human exposure.

No data were available to evaluate the teratogenicity or chromosomal effects of this compound in humans.

No case report or epidemiological study of the carcinogenicity of symphytine was available to the Working Group.

5.3 Evaluation

No evaluation of the carcinogenicity of symphytine to experimental animals could be made. Results of experiments in rats provide limited evidence that the leaves and roots of Symphytum officinale L. are carcinogenic to experimental animals. In the absence of epidemiological data, no evaluation of the carcinogenicity of symphytine to humans could be made.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 72: Group 3)

Synonyms


Last updated: 16 April 1998






















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