VOL.: 31 (1983) (p. 213)
Chem. Abstr. Name: 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-
The 3-rhamnoglucoside of quercetin (rutin) was tested in rats and hamsters by administration in the diet. No evidence of carcinogenicity was found.
Quercetin is mutagenic in bacteria and insects and caused gene conversion in yeast. Equivocal results were obtained with respect to mutations in mammalian cells in vitro. It induced chromosomal anomalies in cultured cells, but equivocal results were obtained in the micronucleus test in vivo. Quercetin induced morphological transformation of hamster embryo cells in vitro. There is sufficient evidence that quercetin is active in short-term tests.
In one experiment with rats, no teratogenic effect was seen.
No data were available to evaluate the teratogenicity or chromosomal effects of this compound in humans.
No case report or epidemiological study of the carcinogenicity of quercetin was available to the Working Group.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluations: Suppl. 7 (1987) (p. 71: Group 3); see also Vol. 40 (1986) (Bracken fern); Vol. 73 (1999)
See Also: Toxicological Abbreviations Quercetin (IARC Summary & Evaluation, Volume 73, 1999)