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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

CINNAMYL ANTHRANILATE

VOL.: 31 (1983) (p. 133)

CAS No.: 87-29-6
Chem. Abstr. Name: Benzoic acid, 2-amino-, 3-phenyl-2-propenyl ester

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Cinnamyl anthranilate was tested for carcinogenicity in mice and rats by administration in the diet and in mice by intraperitoneal injection. In mice, a dose-related increase in the incidence of hepatocellular tumours was found following its oral administration and an increased incidence of lung tumours following its intraperitoneal injection. The study in rats could not be evaluated.

Cinnamyl anthranilate was not mutagenic to Salmonella typhimurium. The data were inadequate to evaluate the activity of this compound in short-term tests.

No data were available to evaluate the teratogenicity of this compound to experimental animals.

5.2 Human data

Cinnamyl anthranilate has been used since at least 1939, but its use during the last few years has diminished. Its consumption as a flavouring agent and to a lesser extent as a fragrance in cosmetics are sources of exposure for the general population.

No data were available to evaluate the teratogenicity or chromosomal effects of this compound in humans.

No case report or epidemiological study of the carcinogenicity of cinnamyl anthranilate was available to the Working Group.

5.3 Evaluation

There is limited evidence for the carcinogenicity of cinnamyl anthranilate in experimental animals. In the absence of epidemiological data, no evaluation of the carcinogenicity of cinnamyl anthranilate to humans could be made.

For definition of the italicized terms, see Preamble Evaluation.

Previous evaluation: Vol. 16 (1978)

Subsequent evaluation: Suppl. 7 (1987) (p. 60: Group 3); Vol. 77 (2000)

Synonyms


Last updated: 16 April 1998






















    See Also:
       Toxicological Abbreviations
       Cinnamyl anthranilate (WHO Food Additives Series 16)
       CINNAMYL ANTHRANILATE (JECFA Evaluation)
       Cinnamyl anthranilate  (IARC Summary & Evaluation, Volume 77, 2000)