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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

SULFALLATE

VOL.: 30 (1983) (p. 283)

CAS No.: 95-06-7
Chem. Abstr. Name: Carbamodithioic acid, diethyl-, 2-chloro-2-propenyl ester

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Sulfallate (technical grade) was tested for carcinogenicity in one strain of mice and in one strain of rats by administration in the diet. It was carcinogenic in mice, inducing mammary gland tumours in females and lung tumours in males. It was also carcinogenic in rats, inducing mammary gland tumours in females and benign and malignant tumours of the forestomach in males.

No data were available to evaluate the teratogenicity of sulfallate to experimental animals.

Sulfallate was mutagenic to Salmonella typhimurium in the presence of exogenous metabolic activation and to Aspergillus and Streptomyces but not to Saccharomyces cerevisiae with or without metabolic activation. There is sufficient evidence for the mutagenicity of sulfallate in bacterial systems but insufficient evidence for its mutagenicity in mammalian cells or in mammals.

5.2 Human data

Sulfallate was introduced in 1954. Its production and use as a herbicide in agricultural applications are potential sources of exposure, both of workers and of the general population.

No data were available to evaluate the teratogenic or chromosomal effects of sulfallate in humans.

No case report or epidemiological study of the carcinogenicity of sulfallate alone was available to the Working Group. (See also the section 'Cancer Epidemiology of Pesticide Manufacturers, Formulators and Users', in this volume.)

5.3 Evaluation

No data on humans were available.

There is sufficient evidence that sulfallate is carcinogenic to experimental animals.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 72: Group 2B)

Synonyms


Last updated: 16 April 1998






















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