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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

para-BENZOQUINONE DIOXIME

VOL.: 29 (1982) (p. 185)

CAS No.: 105-11-3
Chem. Abstr. Name: 2,5-Cyclohexadiene-1,4-dione, dioxime

5. Summary of Data Reported and Evaluation

5.1 Experimental data

para-Benzoquinone dioxime was tested for carcinogenicity at two dose levels in mice and rats by oral administration. No significant increase in the number of neoplasms was observed in male rats; but in females given the high dose, a significant increase in the number of transitional-cell papillomas and carcinomas of the urinary bladder occurred. In mice, no carcinogenic effect was observed.

No data were available to assess the mutagenicity or teratogenicity of this compound.

5.2 Human data

Occupational exposure to para-benzoquinone dioxime probably occurs during its manufacture, its use as a rubber vulcanizing agent and its conversion to chemical derivatives.

No data were available to assess the mutagenicity or teratogenicity of this compound to man.

No case report or epidemiological study was available to the Working Group.

5.3 Evaluation

There is limited evidence that para-benzoquinone dioxime is carcinogenic to rats.

No case report or epidemiological study was available.

No evaluation could be made of the carcinogenicity of para-benzoquinone dioxime to man.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Vol. 71 (1999)

Synonyms para-Benzoquinone Dioxime


Last updated: 9 April 1998






















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