International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 27 (1982) (p. 227)
CAS No.: 156-10-5
Chem. Abstr. Name: Benzenamine, 4-nitroso-N-phenyl-
5. Summary of Data Reported and Evaluation
5.1 Experimental data
para-Nitrosodiphenylamine (technical grade) was tested in mice and
rats by dietary administration. It produced lesions described as
neoplastic nodules in the livers of male rats. The results of the
study in mice were inconclusive.
No data on the mutagenicity of para-nitrosodiphenylamine were
5.2 Human data
para-Nitrosodiphenylamine has been produced commercially since at
least 1970. Its use as a chemical intermediate could result in
No case report or epidemiological study was available to the Working
The available data are insufficient for an evaluation of the
carcinogenicity of para-nitrosodiphenylamine in experimental animals.
In view of the few data in experimental animals and in the absence of
data on humans, no evaluation of the carcinogenicity of
para-nitrosodiphenylamine to humans could be made.
Subsequent evaluation: Suppl. 7 (1987) (p. 68: Group 3)
- Naugard TKB
Last updated: 8 April 1998