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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

N-NITROSODIPHENYLAMINE

VOL.: 27 (1982) (p. 213)

CAS No.: 86-30-6
Chem. Abstr. Name: Benzenamine, N-nitroso-N-phenyl-

5. Summary of Data Reported and Evaluation

5.1 Experimental data

N-Nitrosodiphenylamine was adequately tested in one experiment in mice and in one experiment in rats by dietary administration. No carcinogenic effects were observed in mice. It was carcinogenic for male and female rats, producing transitional-cell carcinomas of the urinary bladder in animals given the high dose. In other experiments the results were not indicative of carcinogenic effects, but there were various inadequacies in the conducting and/or reporting of these experiments.

N-Nitrosodiphenylamine has been extensively tested in short-term assays in prokaryotes and eukaryotes for mutagenicity and other chromosomal effects. It was not mutagenic and did not induce unscheduled DNA synthesis or chromosomal damage under any test condition employed.

5.2 Human data

N-Nitrosodiphenylamine has been produced commercially since at least 1945. Its use as a chemical intermediate and as a rubber processing chemical could result in occupational exposure.

No case report or epidemiological study was available to the Working Group.

5.3 Evaluation

There is limited evidence for the carcinogenicity of N-nitrosodiphenylamine in experimental animals.

No evaluation of the carcinogenicity of N-nitrosodiphenylamine to humans could be made.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 67: Group 3)

Synonyms


Last updated: 8 April 1998






















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       Toxicological Abbreviations