International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 27 (1982) (p. 119)
CAS No.: 101-61-1
Chem. Abstr. Name: Benzenamine, 4,4'-methylenebis(N,N-dimethyl)-
5. Summary of Data Reported and Evaluation
5.1 Experimental data
4,4'-Methylenebis(N,N-dimethyl)benzenamine was tested in one
experiment in mice and in one experiment in rats by dietary
administration. It produced liver-cell adenomas in female mice and
thyroid follicular-cell carcinomas in male and female rats given the
4,4'-Methylenebis(N,N-dimethyl)benzenamine was positive in Escherichia
coli repair tests. It was mutagenic to Salmonella typhimurium, both
in vitro and in the murine host-mediated assay. It did not induce
mitotic recombination in yeast, but caused morphological
transformation in hamster embryo cells.
5.2 Human data
4,4'-Methylenebis(N,N-dimethyl)benzenamine has been
produced commercially since at least 1921. Its use as a dye
intermediate could result in occupational exposure.
No case report or epidemiological study was available to the Working
There is limited evidence for the carcinogenicity of
4,4'-methylenebis(N,N-dimethyl)benzenamine in experimental animals.
No evaluation of the carcinogenicity of
4,4'-methylenebis(N,N-dimethyl)benzenamine to humans could be made.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 66: Group 3)
- Methane base
- Michler's Base
- Michler's hydride
- Michler's methane
Last updated: 8 April 1998