IPCS INCHEM Home

International Agency for Research on Cancer (IARC) - Summaries & Evaluations

4-CHLORO-ortho-PHENYLENEDIAMINE AND 4-CHLORO-meta-PHENYLENEDIAMINE

VOL.: 27 (1982) (p. 81)

4-Chloro-ortho-phenylenediamine
CAS No.: 95-83-0
Chem. Abstr. Name: 1,2-Benzenediamine, 4-chloro-

4-Chloro-meta-phenylenediamine
CAS No.: 5131-60-2
Chem. Abstr. Name: 1,3-Benzenediamine, 4-chloro-

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Both 4-chloro-ortho-phenylenediamine and 4-chloro-meta-phenylenediamine were tested for carcinogenicity in mice and rats by dietary administration. 4-Chloro-ortho-phenylenediamine was carcinogenic in mice, producing hepatocellular carcinomas in animals of both sexes, and in rats of both sexes, producing benign and malignant tumours of the urinary bladder. The results of the studies with 4-chloro-meta-phenylenediamine in mice were inconclusive; those in rats were not indicative of a carcinogenic effect.

4-Chloro-ortho-phenylenediamine was mutagenic to Salmonella typhimurium after metabolic activation. No data were available on the mutagenicity of 4-chloro-meta-phenylenediamine.

5.2 Human data

4-Chloro-ortho- and 4-chloro-meta-phenylenediamine have been produced commercially since the early 1940s. The extent of present human exposure is unknown. Both have been patented for use as hair-dye components.

No case report or epidemiological study was available to the Working Group, but see Appendix 1, in this volume.

5.3 Evaluation

There is sufficient evidence for the carcinogenicity of 4-chloro ortho-phenylenediamine in experimental animals. In the absence of data on humans, 4-chloro-ortho-phenylenediamine should be regarded, for practical purposes, as if it presented a carcinogenic risk to humans.

The available data were inadequate to evaluate the carcinogenicity of 4-chloro-meta-phenylenediamine in experimental animals. No evaluation of the carcinogenicity of 4-chloro-meta-phenylenediamine to humans could be made.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 60: 4-chloro-ortho-phenylenediamine - Group 2B; 4-chloro-meta-phenylenediamine - Group 3)

Synonyms for 4-Chloro-ortho-phenylenediamine

Synonyms for 4-Chloro-meta-phenylenediamine


Last updated: 8 April 1998






















    See Also:
       Toxicological Abbreviations