VOL.: 26 (1981) (p. 137)
CCNU can induce embryo- and fetolethality in rats and rabbits at doses nontoxic to the mother and a variety of severe teratogenic effects in rats.
It is mutagenic in Salmonella typhimurium and in Chinese hamster lung cells.
The frequency of sister chromatid exchanges is increased in the lymphocytes of patients who have been treated with CCNU. No data were available to evaluate the teratogenic or mutagenic potential of this drug in humans.
Several case reports describe the development of acute nonlymphocytic leukaemia in cancer patients who received CCNU. With one exception, all such patients had also received other cytotoxic agents and/or irradiation. No epidemiological study of CCNU as a single agent was available to the Working Group.
This chemical should be regarded for practical purposes as if it presented a carcinogenic risk to humans.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987)
See Also: Toxicological Abbreviations