VOL.: 26 (1981) (p. 79)
When tested in mice by skin application together with ultra-violet B irradiation, BCNU caused an earlier appearance of skin tumours.
BCNU is embryo- and fetolethal in rats and rabbits at doses nontoxic to the mother and can induce a variety of severe teratogenic effects in rats.
BCNU is mutagenic in bacteria, Drosophila melanogaster and mammalian cells. It also produces chromosomal aberrations in mammalian cells both in cell culture and in vivo.
No data were available to evaluate the teratogenic potential or the mutagenicity or chromosomal effects of BCNU in humans.
BCNU has been associated in case reports with the development of acute nonlymphocytic leukaemia following treatment of primary malignant diseases. In all such cases, BCNU was administered with other anticancer therapies known or suspected of being carcinogenic. No epidemiological study was available.
This chemical should be regarded for practical purposes as if it presented a carcinogenic risk to humans.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987)
See Also: Toxicological Abbreviations