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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

PHENOXYBENZAMINE AND
PHENOXYBENZAMINE HYDROCHLORIDE

VOL.: 24 (1980) (p. 185)

Phenoxybenzamine
CAS No.: 59-96-1
Chem. Abstr. Name: Benzenemethanamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-

Phenoxybenzamine hydrochloride
CAS No.: 63-92-3
Chem. Abstr. Name: Benzenemethanamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-, hydrochloride

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Phenoxybenzamine was tested intraperitoneally in mice; it produced an increased incidence of lung tumours.

Phenoxybenzamine hydrochloride was tested intraperitoneally in mice and rats; it produced local peritoneal sarcomas in animals of both sexes.

Attention is drawn to the absence of adequate studies on the mutagenicity or teratogenicity of phenoxybenzamine or its hydrochloride.

5.2 Human data

Phenoxybenzamine hydrochloride has limited use as an a-adrenergic receptor blocking agent.

No case reports or epidemiological studies were available to the Working Group.

5.3 Evaluation

There is sufficient evidence that phenoxybenzamine hydrochloride is carcinogenic in experimental animals by intraperitoneal administration. No data on humans were available.

Previous evaluation: Vol. 9 (1975)

Subsequent evaluation: Suppl. 7 (1987) (p. 70: Phenoxybenzamine hydrochloride - Group 2B)

For definition of terms, see Preamble Evaluation.

Synonyms for Phenoxybenzamine

Synonyms for Phenoxybenzamine hydrochloride


Last updated: 7 April 1998






















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       Toxicological Abbreviations