International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 24 (1980) (p. 125)
CAS No.: 3771-19-5
Chem. Abstr. Name: Propanoic acid, 2-methyl-2-[4-(1,2,3,4-tetrahydro-1-naphthalenyl)phenoxy]-
5. Summary of Data Reported and Evaluation
5.1 Experimental data
Nafenopin was tested in acatalasemic mice (a strain with an unstable
catalase gene) and in male rats by oral administration: it produced
hepatocellular carcinomas in both species. A low incidence of
pancreatic tumours was also observed in rats.
It was not mutagenic in Salmonella typhimurium.
5.2 Human data
Nafenopin has been suggested for use as a hypolipidaemic agent.
No case reports or epidemiological studies were available to the
There is sufficient evidence for the carcinogenicity of nafenopin in
experimental animals. For practical purposes, nafenopin should be
regarded as if it presented a carcinogenic risk to humans.
Subsequent evaluation: Suppl. 7 (1987) (p. 67: Group 2B)
For definition of terms, see Preamble Evaluation.
Synonyms for Nafenopin
- CH 13-437
- CIBA 13437 Su
- C 13437 Su
- 2-Methyl-2-[4-(1,2,3,4-tetrahydro-1-naphthalenyl)phenoxy]propanoic acid
- 2-Methyl-2-[para-(1,2,3,4-tetrahydro-1-naphthyl)phenoxy]propionic acid
- a-Methyl-a-(para-1,2,3,4-tetrahydronaphth-1-ylphenoxy) propionic acid
- Nafenoic acid
- Su 13437
Last updated: 7 April 1998