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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

STREPTOZOTOCIN

VOL.: 17 (1978) (p. 337)

CAS No.: 18883-66-4
Chem. Abstr. Name: 2-Deoxy-2{[methyl-nitrosoamino)carbonyl]amino}D-glucopyranose

4. Summary of Data Reported and Evaluation

4.1 Experimental data

Streptozotocin is carcinogenic in mice, rats and Syrian golden and Chinese hamsters following its intravenous or intraperitoneal administration. It produces benign and malignant tumours of the liver and kidney and islet-cell tumours of the pancreas. It is carcinogenic after its administration in single doses.

4.2 Human data

No adequate data on humans were available to the Working Group, but the chemotherapeutic use of streptozotocin indicates the existence of an exposed group.

4.3 Evaluation

There is sufficient evidence of a carcinogenic effect of streptozotocin in several experimental animal species. Although no epidemiological data were available (and efforts should be directed toward this end), streptozotocin should be regarded for practical purposes as it were carcinogenic to humans.

Previous evaluation: Vol. 4 (1974)

Subsequent evaluation: Suppl. 7 (1987) (p. 72: Group 2B)

For definition of terms, see Preamble Evaluation.

Synonyms


Last updated: 27 March 1998






















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