International Agency for Research on Cancer (IARC) - Summaries & Evaluations
N-NITROSOSARCOSINE
VOL.: 17 (1978) (p. 327)
CAS No.: 13256-22-9
Chem. Abstr. Name: N-Methyl-N-nitroso-glycine
5. Summary of Data Reported and Evaluation
5.1 Experimental data
N-Nitrososarcosine is carcinogenic in mice and rats. It produces
carcinomas of the nasal cavities in mice and oesophageal carcinomas
in rats after its oral administration, and liver-cell carcinomas
in newborn mice after its intraperitoneal injection.
5.2 Human data
No case reports or epidemiological studies were available to the
Working Group. Available information on occurrence suggests that the
general population way be exposed sporadically to low levels of this
substance; however, no exposed group suitable for an epidemiological
investigation has yet been identified.
5.3 Evaluation
There is sufficient evidence of a carcinogenic effect of
N-nitrososarcosine in two experimental animal species. Although no
epidemiological data were available, N-nitrososarcosine should be
regarded for practical purposes as if it were carcinogenic to
humans.
Subsequent evaluation: Suppl. 7 (1987) (p. 68: Group 2B)
For definition of terms, see Preamble Evaluation.
Synonyms
- N-Nitrosomethylglycine
- NSAR
Last updated: 27 March 1998