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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

N-NITROSOSARCOSINE

VOL.: 17 (1978) (p. 327)

CAS No.: 13256-22-9
Chem. Abstr. Name: N-Methyl-N-nitroso-glycine

5. Summary of Data Reported and Evaluation

5.1 Experimental data

N-Nitrososarcosine is carcinogenic in mice and rats. It produces carcinomas of the nasal cavities in mice and oesophageal carcinomas in rats after its oral administration, and liver-cell carcinomas in newborn mice after its intraperitoneal injection.

5.2 Human data

No case reports or epidemiological studies were available to the Working Group. Available information on occurrence suggests that the general population way be exposed sporadically to low levels of this substance; however, no exposed group suitable for an epidemiological investigation has yet been identified.

5.3 Evaluation

There is sufficient evidence of a carcinogenic effect of N-nitrososarcosine in two experimental animal species. Although no epidemiological data were available, N-nitrososarcosine should be regarded for practical purposes as if it were carcinogenic to humans.

Subsequent evaluation: Suppl. 7 (1987) (p. 68: Group 2B)

For definition of terms, see Preamble Evaluation.

Synonyms


Last updated: 27 March 1998






















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