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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

N-NITROSODI-n-PROPYLAMINE

VOL.: 17 (1978) (p. 177)

CAS No.: 621-64-7
Chem. Abstr. Name: N-nitroso-N-propyl-1-propanamine

5. Summary of Data Reported and Evaluation

5.1 Experimental data

N-Nitrosodi-n-propylamine is carcinogenic in rats after its oral administration and in rats and hamsters after its subcutaneous injection. It produces benign and malignant tumours of the liver, kidney, oesophagus and respiratory tract. The metabolite N-nitroso-N-(2-hydroxy-n-propyl)-n-propylamine is also carcinogenic in rats and hamsters: it produces benign and malignant tumours of the respiratory tract and liver after its subcutaneous injection.

5.2 Human data

No case reports or epidemiological studies were available to the Working Group. Available information on occurrence suggests that the general population may be exposed sporadically to low levels of N-nitrosodi-n-propylamine; however, no exposed group suitable for an epidemiological investigation has yet been identified. The report of relatively high levels in one pesticide formulation may permit the identification of exposed groups.

5.3 Evaluation

There is sufficient evidence of a carcinogenic effect of N-nitrosodi-n-propylamine in two experimental animal species. Although no epidemiological data were available (and efforts should be directed toward this end), N-nitrosodi-n-propylamine should be regarded for practical purposes as if it were carcinogenic to humans.

Subsequent evaluation: Suppl. 7 (1987) (p. 68: Group 2B)

For definition of terms, see Preamble Evaluation.

Synonyms


Last updated: 27 March 1998






















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