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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

para-PHENYLENEDIAMINE (HYDROCHLORIDE)

VOL.: 16 (1978) (p. 125)

para-Phenylenediamine
CAS No.: 106-50-3
Chem. Abstr. Name: 1,4-Benzenediamine

para-Phenylenediamine hydrochloride
CAS No.: 624-18-0
Chem. Abstr. Name: 1,4-Benzenediamine dihydrochloride

5. Summary of Data Reported and Evaluation

5.1 Animal data

para-Phenylenediamine has been inadequately tested in mice by skin application and in rats by oral and subcutaneous administration. Studies in mice in which para-phenylenediamine as a constituent of hair-dye preparations was tested by skin application cannot be evaluated. No evaluation of the carcinogenicity of this compound can be made.

5.2 Human data

No case reports or epidemiological studies were available to the Working Group (see, however, 'General Remarks on the Substances Considered', in this volume).

Subsequent evaluation: Suppl. 7 (1987) (p. 70: Group 3)

For definition of Groups, see Preamble Evaluation.

Synonyms for para-Phenylenediamine

Synonyms for para-Phenylenediamine hydrochloride


Last updated: 26 March 1998






















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       Toxicological Abbreviations