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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

BENZYL VIOLET 4B

VOL.: 16 (1978) (p. 153)

CAS No.: 1694-09-3
Chem. Abstr. Name: N-(4-{[4-(Dimethylamino)phenyl][4-{ethyl[(3-sulfophenyl)methyl]amino}-
phenyl]methylene}-2,5-cyclohexadien-l-ylidene)-N-ethyl-3-sulfobenzenemethanaminium hydroxide
inner salt, sodium salt

5. Summary of Data Reported and Evaluation

5.1 Animal data

Benzyl violet 4B is carcinogenic in rats following its oral or subcutaneous administration: it produced mammary carcinomas and squamous-cell carcinomas of the skin after its oral administration to female rats and local fibrosarcomas following its subcutaneous injection in male and female rats. It also increased the incidence of benign mammary tumours in female rats following ambient exposure.

5.2 Human data

No case reports or epidemiological studies were available to the Working Group.

Subsequent evaluation: Suppl. 7 (1987) (p. 58: Group 2B)

For definition of Groups, see Preamble Evaluation.

Synonyms


Last updated: 26 March 1998






















    See Also:
       Toxicological Abbreviations
       Benzyl violet 4B (WHO Food Additives Series 12)
       BENZYL VIOLET 4B (JECFA Evaluation)