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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

PHENYLBUTAZONE and OXYPHENBUTAZONE

VOL.: 13 (1977) (p. 183)

Phenylbutazone
CAS No.: 50-33-0
Chem. Abstr. Name: 4-Butyl-1,2-diphenyl-3,5-pyrazolidinedione

Oxyphenbutazone
CAS No.: 129-20-4
Chem. Abstr. Name: 4-Butyl-1-(4-hydroxyphenyl)-2-phenyl-3, 5-pyrazolidinedione

5. Summary of Data Reported and Evaluation

5.1 Animal data

No data were available to the Working Group.

5.2 Human data

A number of cases of leukaemia were reported between 1960 and 1966 in subjects treated with phenylbutazone or oxyphenbutazone. The available evidence is, however, insufficient to substantiate the suggestion that use of phenylbutazone or oxyphenbutazone is related to subsequent development of leukaemia.

Subsequent evaluation of Phenylbutazone: Suppl. 7 (1987)

Subsequent evaluation of Oxyphenbutazone: Suppl. 7 (1987) (p. 69: Group 3)

For definition of Groups, see Preamble Evaluation.

Synonyms for Phenylbutazone

Synonyms for Oxyphenbutazone


Last updated: 25 March 1998






















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       Toxicological Abbreviations