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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

NIRIDAZOLE

VOL.: 13 (1977) (p. 123)

CAS No.: 61-57-4
Chem. Abstr. Name: 1-(5-Nitro-2-thiazolyl)-2-imidazolidinone

5. Summary of Data Reported and Evaluation

5.1 Animal data

Niridazole is carcinogenic in mice and hamsters after its oral administration: in mice it induced lymphomas and tumours of the lung, stomach, mammary gland, ovary and bladder; in hamsters it produced tumours of the forestomach and papillomas of the urinary bladder. Infection of treated mice and hamsters with Schistosoma mansoni cercariae did not affect the carcinogenicity of the compound.

5.2 Human data

No case reports or epidemiological studies were available to the Working Group.

Subsequent evaluation: Suppl. 7 (1987) (p. 67: Group 2B)

For definition of Groups, see Preamble Evaluation.

Synonyms


Last updated: 25 March 1998






















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