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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

HYCANTHONE and HYCANTHONE MESYLATE

VOL.: 13 (1977) (p. 91)

Hycanthone
CAS No.: 3105-97-3
Chem. Abstr. Name: 1-{[2-(Diethylamino)ethyl]amino}-4- (hydroxymethyl)-9H-thioxanthen-
9-one

Hycanthone mesylate
CAS No.: 23255-93-8
Chem. Abstr. Name: 1-{[2-(Diethylamino)ethyl]amino}-4-(hydroxymethyl)-9H-thioxanthen-
9-one, monomethanesulfonate (salt)

5. Summary of Data Reported and Evaluation

5.1 Animal data

Hycanthone mesylate is carcinogenic in mice previously infected with Schistosoma mansoni: a significant increase in the incidence of hepatocellular carcinomas was observed in these mice following repeated intramuscular injections of this compound. The limited data available are not sufficient to evaluate whether hycanthone mesylate is carcinogenic in non-infected animals.

5.2 Human data

No case reports or epidemiological studies were available to the Working Group.

Subsequent evaluation of Hycanthone mesylate: Suppl. 7 (1987) (p. 64: Group 3)

For definition of Groups, see Preamble Evaluation.

Synonyms for Hycanthone

Synonyms for Hycanthone mesylate


Last updated: 25 March 1998






















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       Toxicological Abbreviations