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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

CHLOROPROPHAM

VOL.: 12 (1976) (p. 55)

CAS No.: 101-21-3
Chem. Abstr. Name: (3-Chlorophenyl)carbamic acid, 1-methylethyl ester

5. Summary of Data Reported and Evaluation

5.1 Animal carcinogenicity data

Chloropropham produced no carcinogenic effects when administered orally to mice, rats and hamsters or subcutaneously to mice. Doses used in the studies in mice and hamsters did not necessarily correspond to the maximum tolerated doses.

In one experiment with oral administration in mice, chloropropham acted as an initiator of skin carcinogenesis. This was not confirmed in a subsequent experiment.

5.2 Human carcinogenicity data

No case reports or epidemiological studies were available to the Working Group.

Subsequent evaluation: Suppl. 7 (1987) (p. 60: Group 3)

For definition of Groups, see Preamble Evaluation.

Synonyms


Last updated: 25 March 1998






















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